Acute severe stress triggers the body’s “fight-or-flight response”. Your heart beats faster, your blood pressure increases and you breathe harder. Your muscles become tense, you may feel nauseous. Wild animals can actually die of stress during capture and relocation as a result of a condition known as “capture myopathy”. Muscles are damaged as the animal struggles to escape; the damaged muscle releases toxic substances into the bloodstream, causing kidney failure, high temperatures and sometimes death or a subsequent deterioration in health (Reference 1).

While few cats have been documented as suffering from “capture myopathy”, restraining a struggling, terrified cat for a procedure at the vet clinic has a potential to cause physical as well as emotional damage.  If pre-visit medications aren’t enough, the cat owner has a choice: fear or sedation at the vet?

Fear or sedation at the vet?


Sedation can be a gift for a fearful and/or fractious cat. Sedation can (Reference 2):

  • provide comfort and analgesia while reducing anxiety and stress
  • prevent injury to veterinary staff
  • promote a better hospital experience for cats undergoing minor procedures

When properly done, sedation can be a safe procedure for most cats. On the other hand, general anesthesia may be more appropriate for cats with neurological problems, cardiac or respiratory disorders (Reference 2).

sedation vs general anesthesia


Sedation is similar to general anesthesia: the drugs used can cause unconsciousness, amnesia and loss of protective reflexes such as gagging and swallowing (if possible, the cat is fasted prior to the procedure). The risks to the sedated cat are similar to those encountered by the anesthetized cat: the most common issues are cardiovascular and respiratory (Reference 2).  

Sedation is chosen for minor procedures where the cat will be only be under the effects of sedative drugs for a short time. A cat may be sedated to acquire blood and urine samples, have x-rays of painful limbs, or have an abscess flushed and stitched up. In such brief procedures, typically an airway is not established with an endotracheal tube nor is an intravenous catheter placed. The goal is to finish the necessary tasks and wake the cat up, returning them to a normal physiologic state as soon as possible.

Good practice dictates that the veterinary team be prepared to transition to general anesthesia if necessary, providing oxygen, intubating the cat and placing an intravenous catheter for fluid therapy if needed.

Monitoring (Reference 2) during sedation is not as comprehensive as that of general anesthesia due to time constraints. An abbreviated protocol follows the cat’s physiologic status.

  • monitor depth of sedation – eye blink reflex
  • measuring oxygen saturation in the blood (pulse oximetry)
  • measuring pulse rate and blood pressure

Comfort and Pain Relief


Sedation protocols for cats are typically a combination of a pain medication (usually an opioid) and a sedative. The combination of the two drugs produces a greater sedative effect compared with either drug given alone. Lower doses of the drugs can be used when they are given together (Reference 2), reducing adverse cardiac and respiratory side effects.

The drugs can given intramuscularly (IM) or intravenously (IV) depending on the drug combination. IM protocols are popular because is often easier to give a frightened, struggling cat an injection in the muscle compared with trying to inject drugs in a vein.

Pre-visit medications can be an adjunct to the sedation procedure, reducing the dose of sedative drugs needed and making administration of these drugs less stressful.

recovery


A warm, dark, quiet area allows cats waking up from sedation or anesthesia to be monitored to ensure a smooth recovery. Additional pain medication may be administered and food may be offered if appropriate.

returning home


  • Watch your cat closely once they are home. Consider confining them to a room with all their resources so that they can safely settle back into the home environment and routine. Be sure to check in on them until the effects of the sedative drugs have worn off.
  • Cats identify each other by smell. In multi-cat homes, a cat returning from the vet clinic has picked up the smell of the hospital and may be “shunned” by their housemates. Keeping the returning cat separate from their housemates followed by a reintroduction is appropriate here.
  • See “Aggression Between Cats After a Vet Visit”

 

The choice: Fear or Sedation at the Vet?
In cats with fractious temperaments or showing fearful behavior, sedation can replace moments of sheer terror with a better hospital experience. Gone is the struggle, muscle tension, and fear associated with full-body restraint. The gift of sedation can help cats live longer and healthier lives due to better veterinary care.

references

  1. Breed D, Meyer LCR, Steyl JCA, Goddard A, Burroughs R, Kohn TA. Conserving wildlife in a changing world: Understanding capture myopathy-a malignant outcome of stress during capture and translocation. Conserv Physiol. 2019 Jul 5;7(1):coz027. doi: 10.1093/conphys/coz027. PMID: 31304016; PMCID: PMC6612673.
  2. Simon BT, Steagall PV. Feline procedural sedation and analgesia: When, why and how. J Feline Med Surg. 2020 Nov;22(11):1029-1045. doi: 10.1177/1098612X20965830. PMID: 33100168; PMCID: PMC10814218.

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A relaxed, calm cat approaches a veterinary staff member.

Veterinary medicine has markedly improved for companion animals – we recognize that cats and dogs experience pain and suffering, which in turn affects their quality of life. Routine checkups, vaccinations,  and dental cleanings reduce disease and improve the health and welfare of our pets.

Cats are becoming members of the family and not just valued mousers.  There is a trend away from brute force handling of cats to “get it (blood sample, vaccination) done” to trying to make the vet visit better for cats, avoiding fear and arousal as much as possible.

make the vet visit better for cats


Some of the programs in place to help veterinary staff address the feline patient include:

  • Cat Friendly Practice (Reference 1)
  • Fear Free Program (Reference 2)
  • Low-Stress Handling (Reference 3)

All of these initiatives have the same goal – to deliver medical care to animals without the complications of fear and arousal. We want to avoid the trauma that can result from an unpleasant or frightening event. We want to avoid overwhelming an animal’s ability to cope and triggering survival mechanisms such as fight, freeze or flight.

How can we make the vet visit better for cats? When they arrive at the veterinary clinic, the cat has been taken out of his home environment and transported to a strange place – it smells of other animals, many of whom are afraid; it may be cold and noisy. The cat is most likely scared and anxious, not knowing what will happen next.

How we handle cats in the veterinary hospital has direct consequences on the cat’s welfare. To reduce stress and bad memories, we start with a quiet exam room and an assessment of how kitty is doing today.

the behavior traffic light – Go? Caution? stop!


green – go?

  • The “green” cat is relaxed and may approach veterinary staff.
  • Handling may include petting if the cat solicits it.
  • Exam can be in the cat’s carrier, on the owner’s lap, or wherever the cat is comfortable.
  • Restraint is minimal – handling focuses on stabilizing the cat.
  • Food/toys may be used to distract the cat and keep them happy.

yellow – caution?

  • The “yellow” cat shows early signs of anxiety or fear – they are tense, ears flattened, the tail may be tucked under.
  • Handling may include a towel to give the cat a place to hide and feel more secure.
  • Position or location may change as needed to gain the cat’s cooperation (see “Preparing for the Cat Friendly Exam”).
  • The visit should be prioritized, with the exam number one on the list.
  • Optional procedures like a nail trim may be put off for another day.

Some cats will freeze and seem easy to handle but they are fearful and may “explode” with aggression.

red – stop!

  • A “red” cat may hiss, growl, bite or swat at someone trying to handle them.
  • They actively resist handling.
  • These cats are fearful and defensive and may try to hide.
  • Handling should be stopped immediately to avoid injury to the cat or the handler.
  • If the cat calms down after a break, a limited exam can be attempted.
  • Sedation or anesthesia will be recommended instead of force for urgent procedures.

Can “stop” make the vet visit better for cats?


It is important to realize that the cat learns from traumatic handling. They are likely to repeat the same behavior in a similar situation; they will associate the room, the people, the type of touch with the traumatic experience. STOP” allows us to do a “reset” to that point before things started to go wrong and try to make the vet visit better for cats.

Sedation


Sedative drugs cause a state of calmness or sleepiness. Sedating cats who are fractious or fearful allow us to provide them with pain relief and reduce their anxiety and stress, while performing diagnostics and minor procedures.

In urgent cases, sedation is an option for the “red” cat who does not have a history of health issues, or if a limited exam is possible and does not present any red flags.

In non-urgent situations, the owner may consider trying pre-visit medication for a repeat visit, with the option of sedation if needed. 

What are the risks of sedation? These questions will be answered in the next post.

references

  1. Cat Friendly Practice ® Program. © Copyright 2012 – 2025 International Cat Care and Feline Veterinary Medical Association. https://catvets.com/cat-friendly/cfp/. Viewed 9/2025
  2. Fear Free®. © 2025 Fear Free. All rights reserved. https://www.fearfree.com/. Viewed 9/2025
  3. Dr. Sophia Yin’s Low-Stress Handling. ©2025 Veterinary Information Network. All rights reserved https://cattledogpublishing.com/ Viewed 9/2025

 

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